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SMILES: Cc1n[nH]c(C)c1-c1cc(ccn1)C(=O)c1nc2nc(ccc2[nH]1)N1CCNCC1

InChI Key: InChIKey=VZYUNJILORXRQM-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 107759   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cyclin-dependent kinase 4


(Oryctolagus cuniculus (Rabbit))		BDBM107759
PNG
(US8598217, 169)
Show SMILES Cc1n[nH]c(C)c1-c1cc(ccn1)C(=O)c1nc2nc(ccc2[nH]1)N1CCNCC1
Show InChI InChI=1S/C21H22N8O/c1-12-18(13(2)28-27-12)16-11-14(5-6-23-16)19(30)21-24-15-3-4-17(25-20(15)26-21)29-9-7-22-8-10-29/h3-6,11,22H,7-10H2,1-2H3,(H,27,28)(H,24,25,26)
UniProtKB/TrEMBL

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PC sid
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Similars
US Patent
n/an/a 260n/an/an/an/a7.5n/a



Astex Therapeutics Ltd.; Novartis AG

US Patent


Assay Description
A 384-well microtiter Lance TR-FRET (time-resolved-fluorescence energy transfer) endpoint assay was used for CDK4/cyclin D1 kinase activity measureme...

US Patent US8598217 (2013)


BindingDB Entry DOI: 10.7270/Q2BG2MN8
More data for this
Ligand-Target Pair