BDBM107770 US8598155, 5

SMILES: Cc1nc(-c2cnn(C)c2-c2ccc(Cl)cn2)c2c(ncnn12)N1CCC1

InChI Key: InChIKey=CSENBHMOZDDBTJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 107770   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM107770 (US8598155, 5) Show SMILES Cc1nc(-c2cnn(C)c2-c2ccc(Cl)cn2)c2c(ncnn12)N1CCC1 Show InChI InChI=1S/C18H17ClN8/c1-11-24-15(17-18(26-6-3-7-26)21-10-23-27(11)17)13-9-22-25(2)16(13)14-5-4-12(19)8-20-14/h4-5,8-10H,3,6-7H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPA				J Med Chem 61: 1001-1018 (2018) BindingDB Entry DOI: 10.7270/Q2ZS2ZZ4
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM107770 (US8598155, 5) Show SMILES Cc1nc(-c2cnn(C)c2-c2ccc(Cl)cn2)c2c(ncnn12)N1CCC1 Show InChI InChI=1S/C18H17ClN8/c1-11-24-15(17-18(26-6-3-7-26)21-10-23-27(11)17)13-9-22-25(2)16(13)14-5-4-12(19)8-20-14/h4-5,8-10H,3,6-7H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.19	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modifie...				US Patent US8598155 (2013) BindingDB Entry DOI: 10.7270/Q26T0K8C
					More data for this Ligand-Target Pair