BindingDB PrimarySearch

BDBM10838 3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol::Meridianin A

SMILES: Nc1nccc(n1)-c1c[nH]c2cccc(O)c12

InChI Key: InChIKey=SZOKTSDFOPVLFD-UHFFFAOYSA-N

Data: 7 KI 13 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 10838
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation counting				Bioorg Med Chem 19: 5756-62 (2011) Article DOI: 10.1016/j.bmc.2011.08.033 BindingDB Entry DOI: 10.7270/Q25X29BF
University of South Florida Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	684	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from 5-HT1A receptor after 1.5 hrs by scintillation counting				Bioorg Med Chem 19: 5756-62 (2011) Article DOI: 10.1016/j.bmc.2011.08.033 BindingDB Entry DOI: 10.7270/Q25X29BF
University of South Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.35E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Displacement of [3H]WIN35428 from DAT after 1.5 hrs by scintillation counting				Bioorg Med Chem 19: 5756-62 (2011) Article DOI: 10.1016/j.bmc.2011.08.033 BindingDB Entry DOI: 10.7270/Q25X29BF
University of South Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Displacement of [3H]QNB from muscarinic acetylcholine M5 receptor after 1.5 hrs by scintillation counting				Bioorg Med Chem 19: 5756-62 (2011) Article DOI: 10.1016/j.bmc.2011.08.033 BindingDB Entry DOI: 10.7270/Q25X29BF
University of South Florida Curated by ChEMBL					More data for this Ligand-Target Pair
D(1B) dopamine receptor (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation counting				Bioorg Med Chem 19: 5756-62 (2011) Article DOI: 10.1016/j.bmc.2011.08.033 BindingDB Entry DOI: 10.7270/Q25X29BF
University of South Florida Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Displacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation counting				Bioorg Med Chem 19: 5756-62 (2011) Article DOI: 10.1016/j.bmc.2011.08.033 BindingDB Entry DOI: 10.7270/Q25X29BF
University of South Florida Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Displacement of [3H]mesulergine from 5-HT2C receptor after 1.5 hrs by scintillation counting				Bioorg Med Chem 19: 5756-62 (2011) Article DOI: 10.1016/j.bmc.2011.08.033 BindingDB Entry DOI: 10.7270/Q25X29BF
University of South Florida Curated by ChEMBL					More data for this Ligand-Target Pair
CDK2/Cyclin A/Cyclin A1 (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK2/cyclin A expressed in insect cells assessed as histone phosphorylation using [33P]gamma-ATP after 30 mins by sci...				Bioorg Med Chem 19: 5756-62 (2011) Article DOI: 10.1016/j.bmc.2011.08.033 BindingDB Entry DOI: 10.7270/Q25X29BF
University of South Florida Curated by ChEMBL					More data for this Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1 (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Inhibition of human PDK1				Bioorg Med Chem Lett 26: 3073-80 (2016) BindingDB Entry DOI: 10.7270/Q2M61N5R
Merck KGaA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 5A (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Displacement of [3H]LSD from 5-HT5A receptor after 1.5 hrs by scintillation counting				Bioorg Med Chem 19: 5756-62 (2011) Article DOI: 10.1016/j.bmc.2011.08.033 BindingDB Entry DOI: 10.7270/Q25X29BF
University of South Florida Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting				Bioorg Med Chem 19: 5756-62 (2011) Article DOI: 10.1016/j.bmc.2011.08.033 BindingDB Entry DOI: 10.7270/Q25X29BF
University of South Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent-like kinase 5 (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Inhibition of CDK5				Bioorg Med Chem 19: 5756-62 (2011) Article DOI: 10.1016/j.bmc.2011.08.033 BindingDB Entry DOI: 10.7270/Q25X29BF
University of South Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Inhibition of CDK1				Bioorg Med Chem 19: 5756-62 (2011) Article DOI: 10.1016/j.bmc.2011.08.033 BindingDB Entry DOI: 10.7270/Q25X29BF
University of South Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9) (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK9/cyclin T expressed in insect cells assessed as pRB fragment (773 to 928) phosphorylation using [33P]gamma-ATP af...				Bioorg Med Chem 19: 5756-62 (2011) Article DOI: 10.1016/j.bmc.2011.08.033 BindingDB Entry DOI: 10.7270/Q25X29BF
University of South Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen Synthase Kinase-3, beta (Rattus norvegicus (rat))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	30
CNRS					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...				Bioorg Med Chem Lett 14: 1703-7 (2004) Article DOI: 10.1016/j.bmcl.2004.01.050 BindingDB Entry DOI: 10.7270/Q2BZ648W
CNRS					More data for this Ligand-Target Pair
cGMP-Dependent Protein Kinase (Bos taurus (bovine))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a	30
CNRS					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...				Bioorg Med Chem Lett 14: 1703-7 (2004) Article DOI: 10.1016/j.bmcl.2004.01.050 BindingDB Entry DOI: 10.7270/Q2BZ648W
CNRS					More data for this Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	30
CNRS					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...				Bioorg Med Chem Lett 14: 1703-7 (2004) Article DOI: 10.1016/j.bmcl.2004.01.050 BindingDB Entry DOI: 10.7270/Q2BZ648W
CNRS					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Inhibition of GSK3-beta				Bioorg Med Chem 19: 5756-62 (2011) Article DOI: 10.1016/j.bmc.2011.08.033 BindingDB Entry DOI: 10.7270/Q25X29BF
University of South Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	7.2	30
CNRS					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...				Bioorg Med Chem Lett 14: 1703-7 (2004) Article DOI: 10.1016/j.bmcl.2004.01.050 BindingDB Entry DOI: 10.7270/Q2BZ648W
CNRS					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM10838 (3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol \| Meridian...) Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	7.2	30
CNRS					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...				Bioorg Med Chem Lett 14: 1703-7 (2004) Article DOI: 10.1016/j.bmcl.2004.01.050 BindingDB Entry DOI: 10.7270/Q2BZ648W
CNRS					More data for this Ligand-Target Pair