BindingDB PrimarySearch

null

SMILES: Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O

InChI Key: InChIKey=IHJCXVZDYSXXFT-UHFFFAOYSA-N

PDB links: 4 PDB IDs match this monomer. 2 PDB IDs contain this monomer as substructures. 2 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 133 hits for monomerid = 10867
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Agri Ibrahim Cecen University Curated by ChEMBL					Assay Description Inhibition of human esterase activity of carbonic anhydrase 1 using 4-nitrophenylacetate as substrate after 3 mins by spectrophotometric analysis				Bioorg Med Chem 21: 1522-5 (2013) Article DOI: 10.1016/j.bmc.2012.08.018 BindingDB Entry DOI: 10.7270/Q2NG4S0C
Agri Ibrahim Cecen University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kochi Medical School Curated by ChEMBL					Assay Description Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method				J Med Chem 50: 381-8 (2007) Article DOI: 10.1021/jm0612057 BindingDB Entry DOI: 10.7270/Q29G5NNH
Kochi Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Ki value against human carbonic anhydrase I				Bioorg Med Chem Lett 15: 971-6 (2005) Article DOI: 10.1016/j.bmcl.2004.12.052 BindingDB Entry DOI: 10.7270/Q25H7H1N
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kochi Medical School Curated by ChEMBL					Assay Description Inhibition of human recombinant CA1				Bioorg Med Chem Lett 16: 2182-8 (2006) Article DOI: 10.1016/j.bmcl.2006.01.044 BindingDB Entry DOI: 10.7270/Q2HM598P
Kochi Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pennsylvania State University Curated by ChEMBL					Assay Description Inhibitory activity against human carbonic anhydrase I at 0.09 uM				Bioorg Med Chem Lett 14: 6001-6 (2004) Article DOI: 10.1016/j.bmcl.2004.09.085 BindingDB Entry DOI: 10.7270/Q23X87D5
Pennsylvania State University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Ki value against human carbonic anhydrase I (hCA I)				Bioorg Med Chem Lett 15: 963-9 (2005) Article DOI: 10.1016/j.bmcl.2004.12.053 BindingDB Entry DOI: 10.7270/Q29887RZ
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibitory activity against human carbonic anhydrase I (hCAI)				Bioorg Med Chem Lett 15: 1149-54 (2005) Article DOI: 10.1016/j.bmcl.2004.12.009 BindingDB Entry DOI: 10.7270/Q2JS9R6Q
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Tampere and Tampere University Hospital Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay				Bioorg Med Chem 23: 2303-9 (2015) Article DOI: 10.1016/j.bmc.2015.03.081 BindingDB Entry DOI: 10.7270/Q2TX3H2M
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Istituto di Biochimica delle Proteine - CNR Curated by ChEMBL					Assay Description Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method				Bioorg Med Chem 22: 4537-43 (2014) Article DOI: 10.1016/j.bmc.2014.07.048 BindingDB Entry DOI: 10.7270/Q2959K68
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay				Bioorg Med Chem Lett 26: 401-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.104 BindingDB Entry DOI: 10.7270/Q2DB83QG
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay				Bioorg Med Chem 24: 1115-20 (2016) Article DOI: 10.1016/j.bmc.2016.01.037 BindingDB Entry DOI: 10.7270/Q26W9CXH
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Recep Tayyip Erdogan University Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay				Bioorg Med Chem Lett 26: 1821-6 (2016) Article DOI: 10.1016/j.bmcl.2016.02.032 BindingDB Entry DOI: 10.7270/Q2GM896M
Recep Tayyip Erdogan University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay				Bioorg Med Chem Lett 26: 1941-6 (2016) Article DOI: 10.1016/j.bmcl.2016.03.014 BindingDB Entry DOI: 10.7270/Q27946J2
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Balikesir University Curated by ChEMBL					Assay Description Inhibition of wild type human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method				Bioorg Med Chem 18: 5498-503 (2010) Article DOI: 10.1016/j.bmc.2010.06.056 BindingDB Entry DOI: 10.7270/Q2CZ37B6
Balikesir University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Centre Scientifique de Monaco Curated by ChEMBL					Assay Description Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay				Bioorg Med Chem Lett 21: 710-4 (2011) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.124 BindingDB Entry DOI: 10.7270/Q26D5T7K
Centre Scientifique de Monaco Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
Universit£ Montpellier II Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5				Bioorg Med Chem 19: 1172-8 (2011) Article DOI: 10.1016/j.bmc.2010.12.048 BindingDB Entry DOI: 10.7270/Q2C53M44
Universit£ Montpellier II Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
Kochi Medical School Curated by ChEMBL					Assay Description Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay				Bioorg Med Chem 19: 5023-30 (2011) Article DOI: 10.1016/j.bmc.2011.06.038 BindingDB Entry DOI: 10.7270/Q24T6JRW
Kochi Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Slovak Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay				Bioorg Med Chem 20: 1403-10 (2012) Article DOI: 10.1016/j.bmc.2012.01.007 BindingDB Entry DOI: 10.7270/Q2VH5P89
Slovak Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase I (CAI)				Bioorg Med Chem Lett 10: 1117-20 (2000) BindingDB Entry DOI: 10.7270/Q2WW7J6M
Universit£ degli Studi Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibitory activity against human cloned carbonic anhydrase isozyme I by esterase assay method.				Bioorg Med Chem Lett 13: 1005-9 (2003) BindingDB Entry DOI: 10.7270/Q2PV6KXV
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi Curated by ChEMBL					Assay Description Inhibition of cloned isozyme, human carbonic anhydrase I				Bioorg Med Chem Lett 11: 575-82 (2001) BindingDB Entry DOI: 10.7270/Q2KW5GJQ
Universit£ degli Studi Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi Curated by ChEMBL					Assay Description Inhibitory activity against human cloned carbonic anhydrase isozyme I (hCA I, cytosolic form).				J Med Chem 42: 2641-50 (1999) Article DOI: 10.1021/jm9900523 BindingDB Entry DOI: 10.7270/Q2J67HMK
Universit£ degli Studi Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi Curated by ChEMBL					Assay Description Inhibitory activity against human recombinant carbonic anhydrase I (CA1)				J Med Chem 42: 3690-700 (1999) Article DOI: 10.1021/jm9901879 BindingDB Entry DOI: 10.7270/Q26Q1XXC
Universit£ degli Studi Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibitory activity against Human carbonic anhydrase I				J Med Chem 45: 1466-76 (2002) BindingDB Entry DOI: 10.7270/Q2N29XN9
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 3 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	9.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kochi Medical School Curated by ChEMBL					Assay Description Inhibition of human recombinant CA 3 assessed as CO2 hydration by stopped flow kinetic assay				Bioorg Med Chem 15: 7229-36 (2007) Article DOI: 10.1016/j.bmc.2007.08.037 BindingDB Entry DOI: 10.7270/Q2TH8NJ9
Kochi Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase (Mycobacterium tuberculosis)	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.17E+4	-6.25	n/a	n/a	n/a	n/a	n/a	8.3	20
Kochi Medical School					Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...				J Med Chem 52: 3116-20 (2009) Article DOI: 10.1021/jm9003126 BindingDB Entry DOI: 10.7270/Q28G8J2G
Kochi Medical School					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Mycobacterium tuberculosis)	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.25E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay				Bioorg Med Chem Lett 19: 6649-54 (2009) Article DOI: 10.1016/j.bmcl.2009.10.009 BindingDB Entry DOI: 10.7270/Q27W6D4S
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.90E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pennsylvania State University Curated by ChEMBL					Assay Description Inhibitory activity against human carbonic anhydrase IX at 0.09 uM				Bioorg Med Chem Lett 14: 6001-6 (2004) Article DOI: 10.1016/j.bmcl.2004.09.085 BindingDB Entry DOI: 10.7270/Q23X87D5
Pennsylvania State University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase (Methanobacterium thermoautotrophicum)	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	6.21E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pennsylvania State University Curated by ChEMBL					Assay Description Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicum				Bioorg Med Chem Lett 14: 6001-6 (2004) Article DOI: 10.1016/j.bmcl.2004.09.085 BindingDB Entry DOI: 10.7270/Q23X87D5
Pennsylvania State University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	7.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pennsylvania State University Curated by ChEMBL					Assay Description Inhibitory activity against human carbonic anhydrase II at 0.01 uM				Bioorg Med Chem Lett 14: 6001-6 (2004) Article DOI: 10.1016/j.bmcl.2004.09.085 BindingDB Entry DOI: 10.7270/Q23X87D5
Pennsylvania State University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	1.33E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GITAM University Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 2				Bioorg Med Chem Lett 20: 3089-93 (2010) Article DOI: 10.1016/j.bmcl.2010.03.104 BindingDB Entry DOI: 10.7270/Q28C9XGR
GITAM University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibitory concentration against human cystolic isozyme II of Carbonic anhydrase				Bioorg Med Chem Lett 14: 5703-7 (2004) Article DOI: 10.1016/j.bmcl.2004.07.085 BindingDB Entry DOI: 10.7270/Q23N22VW
Università degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Carbonic anhydrase 5A, mitochondrial (Homo sapiens (Human))	BDBM10867 (4-amino-6-chlorobenzene-1,3-disulfonamide \| CHEMBL...) Show SMILES Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibitory concentration against human cystolic isozyme V of Carbonic anhydrase				Bioorg Med Chem Lett 14: 5703-7 (2004) Article DOI: 10.1016/j.bmcl.2004.07.085 BindingDB Entry DOI: 10.7270/Q23N22VW
Università degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair

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