BDBM10903 4-[(3,5-dimethylphenyl)sulfanyl]-5-ethyl-6-methyl-3-nitro-1,2-dihydropyridin-2-one::5-ethyl-6-meth::5-ethyl-6-methyl-3-nitro-4-[(3,5-dimethylphenyl)thio]pyridin-2(1H)-one
SMILES: CCc1c(C)[nH]c(=O)c(c1Sc1cc(C)cc(C)c1)[N+]([O-])=O
InChI Key: InChIKey=HRXHKHXJYOIYON-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM10903 (4-[(3,5-dimethylphenyl)sulfanyl]-5-ethyl-6-methyl-...) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Institut Curie | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 43: 3949-62 (2000) Article DOI: 10.1021/jm0009437 BindingDB Entry DOI: 10.7270/Q2V12315 | |||||||||||
More data for this Ligand-Target Pair |