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BDBM10906 3-Amino-4-(3,5-dimethylbenzoyl)-5-ethyl-6-methylpyridin-2(1H)-one::3-amino-4-[(3,5-dimethylphenyl)carbonyl]-5-ethyl-6-methyl-1,2-dihydropyridin-2-one::4-benzyl pyridinone derivative 14

SMILES: CCc1c(C)[nH]c(=O)c(N)c1C(=O)c1cc(C)cc(C)c1

InChI Key: InChIKey=QLEXSWQYUHOSAR-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 10906   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM10906
PNG
(3-Amino-4-(3,5-dimethylbenzoyl)-5-ethyl-6-methylpy...)
Show SMILES CCc1c(C)[nH]c(=O)c(N)c1C(=O)c1cc(C)cc(C)c1
Show InChI InChI=1S/C17H20N2O2/c1-5-13-11(4)19-17(21)15(18)14(13)16(20)12-7-9(2)6-10(3)8-12/h6-8H,5,18H2,1-4H3,(H,19,21)
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 100n/an/an/an/a8.037



Institut Curie



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 43: 3949-62 (2000)


Article DOI: 10.1016/j.bmcl.2008.12.082
BindingDB Entry DOI: 10.7270/Q2V12315
More data for this
Ligand-Target Pair