BDBM10909 (2R)-2-({6-[benzyl(methyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)butan-1-ol::N6-methyl-(R)-roscovitine::R-2-[6-(Benzyl-methyl-amino)-9-isopropyl-9H-purin-2-ylamino]-butan-1-ol
SMILES: CC[C@H](CO)Nc1nc(N(C)Cc2ccccc2)c2ncn(C(C)C)c2n1
InChI Key: InChIKey=YPYWONAECUVKHY-MRXNPFEDSA-N
PDB links: 1 PDB ID matches this monomer. 2 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Cyclin-Dependent Kinase 1 (CDK1) (Marthasterias glacialis (starfish)) | BDBM10909 ((2R)-2-({6-[benzyl(methyl)amino]-9-(propan-2-yl)-9...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 4.50E+4 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Chinese Academy of Sciences | Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P... | J Biol Chem 280: 31220-9 (2005) Article DOI: 10.1074/jbc.M500805200 BindingDB Entry DOI: 10.7270/Q2Q81B9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK2/CycE (Homo sapiens (Human)) | BDBM10909 ((2R)-2-({6-[benzyl(methyl)amino]-9-(propan-2-yl)-9...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.50E+5 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Chinese Academy of Sciences | Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P... | J Biol Chem 280: 31220-9 (2005) Article DOI: 10.1074/jbc.M500805200 BindingDB Entry DOI: 10.7270/Q2Q81B9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human)) | BDBM10909 ((2R)-2-({6-[benzyl(methyl)amino]-9-(propan-2-yl)-9...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 4.50E+4 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Chinese Academy of Sciences | Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P... | J Biol Chem 280: 31220-9 (2005) Article DOI: 10.1074/jbc.M500805200 BindingDB Entry DOI: 10.7270/Q2Q81B9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-gated calcium channel subunit alpha Cav2.2 (Homo sapiens (Human)) | BDBM10909 ((2R)-2-({6-[benzyl(methyl)amino]-9-(propan-2-yl)-9...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Agonist activity at N-type Cav2.2 channel expressed in tsA201 cell assessed as calcium current by whole-cell patch clamp method | ACS Med Chem Lett 3: 985-990 (2012) Article DOI: 10.1021/ml3002083 BindingDB Entry DOI: 10.7270/Q2BC40P0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Casein Kinase I (Rattus norvegicus (rat)) | BDBM10909 ((2R)-2-({6-[benzyl(methyl)amino]-9-(propan-2-yl)-9...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Chinese Academy of Sciences | Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P... | J Biol Chem 280: 31220-9 (2005) Article DOI: 10.1074/jbc.M500805200 BindingDB Entry DOI: 10.7270/Q2Q81B9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (Homo sapiens (Human)) | BDBM10909 ((2R)-2-({6-[benzyl(methyl)amino]-9-(propan-2-yl)-9...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Chinese Academy of Sciences | Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P... | J Biol Chem 280: 31220-9 (2005) Article DOI: 10.1074/jbc.M500805200 BindingDB Entry DOI: 10.7270/Q2Q81B9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM10909 ((2R)-2-({6-[benzyl(methyl)amino]-9-(propan-2-yl)-9...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Chinese Academy of Sciences | Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P... | J Biol Chem 280: 31220-9 (2005) Article DOI: 10.1074/jbc.M500805200 BindingDB Entry DOI: 10.7270/Q2Q81B9F | |||||||||||
More data for this Ligand-Target Pair |