BDBM11056 (2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile::2-cyanopyrrolidine 10a::CHEMBL381626

SMILES: O=C([C@@H]1CCCN1)N1CCC[C@H]1C#N

InChI Key: InChIKey=SBKBWYVWRSDAJC-IUCAKERBSA-N

Data: 2 KI  5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 11056   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM11056 ((2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2...) Show SMILES O=C([C@@H]1CCCN1)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C10H15N3O/c11-7-8-3-2-6-13(8)10(14)9-4-1-5-12-9/h8-9,12H,1-6H2/t8-,9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	20	-10.4	n/a	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The DPP4 activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and mea...				J Med Chem 49: 3520-35 (2006) Article DOI: 10.1021/jm051283e BindingDB Entry DOI: 10.7270/Q2WS8RG1
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM11056 ((2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2...) Show SMILES O=C([C@@H]1CCCN1)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C10H15N3O/c11-7-8-3-2-6-13(8)10(14)9-4-1-5-12-9/h8-9,12H,1-6H2/t8-,9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro test for inhibitory activity against human dipeptidyl peptidase IV.				Bioorg Med Chem Lett 6: 1163-1166 (1996) Article DOI: 10.1016/0960-894X(96)00190-4 BindingDB Entry DOI: 10.7270/Q279455Q
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM11056 ((2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2...) Show SMILES O=C([C@@H]1CCCN1)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C10H15N3O/c11-7-8-3-2-6-13(8)10(14)9-4-1-5-12-9/h8-9,12H,1-6H2/t8-,9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of DPP4 in human plasma by fluorescence assay				Bioorg Med Chem 15: 641-55 (2006) Article DOI: 10.1016/j.bmc.2006.10.059 BindingDB Entry DOI: 10.7270/Q21N81X1
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM11056 ((2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2...) Show SMILES O=C([C@@H]1CCCN1)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C10H15N3O/c11-7-8-3-2-6-13(8)10(14)9-4-1-5-12-9/h8-9,12H,1-6H2/t8-,9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Inhibition of human DPP4				Bioorg Med Chem 15: 2631-50 (2007) Article DOI: 10.1016/j.bmc.2007.01.041 BindingDB Entry DOI: 10.7270/Q2CV4HDR
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM11056 ((2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2...) Show SMILES O=C([C@@H]1CCCN1)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C10H15N3O/c11-7-8-3-2-6-13(8)10(14)9-4-1-5-12-9/h8-9,12H,1-6H2/t8-,9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Pharma Corporation Curated by ChEMBL					Assay Description Inhibitory concentration against human dipeptidyl-peptidase IV				Bioorg Med Chem Lett 15: 2441-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.077 BindingDB Entry DOI: 10.7270/Q27P8XWJ
					More data for this Ligand-Target Pair
Dipeptidyl peptidase IV (Rattus norvegicus (rat))	BDBM11056 ((2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2...) Show SMILES O=C([C@@H]1CCCN1)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C10H15N3O/c11-7-8-3-2-6-13(8)10(14)9-4-1-5-12-9/h8-9,12H,1-6H2/t8-,9-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Pharma Corporation Curated by ChEMBL					Assay Description Inhibitory concentration against rat dipeptidyl-peptidase IV				Bioorg Med Chem Lett 15: 2441-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.077 BindingDB Entry DOI: 10.7270/Q27P8XWJ
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM11056 ((2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2...) Show SMILES O=C([C@@H]1CCCN1)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C10H15N3O/c11-7-8-3-2-6-13(8)10(14)9-4-1-5-12-9/h8-9,12H,1-6H2/t8-,9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Inhibition of human DPP4				Bioorg Med Chem 15: 2715-35 (2007) Article DOI: 10.1016/j.bmc.2007.01.033 BindingDB Entry DOI: 10.7270/Q2NC60W7
					More data for this Ligand-Target Pair