null
SMILES: Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(O)=O)cc2F)c1
InChI Key: InChIKey=CJHIKUXWIQORDE-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM110598 (US8614234, 66 | US9725433, 66) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 17 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Allergan, Inc. US Patent | Assay Description Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30.mu.g of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered S... | US Patent US8614234 (2013) BindingDB Entry DOI: 10.7270/Q20Z71XF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human)) | BDBM110598 (US8614234, 66 | US9725433, 66) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
ALLERGAN, INC. US Patent | Assay Description The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us... | US Patent US9725433 (2017) BindingDB Entry DOI: 10.7270/Q2ZP4875 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM110598 (US8614234, 66 | US9725433, 66) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
ALLERGAN, INC. US Patent | Assay Description Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l... | US Patent US9725433 (2017) BindingDB Entry DOI: 10.7270/Q2ZP4875 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human)) | BDBM110598 (US8614234, 66 | US9725433, 66) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Allergan, Inc. US Patent | Assay Description Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30.mu.g of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered S... | US Patent US8614234 (2013) BindingDB Entry DOI: 10.7270/Q20Z71XF | |||||||||||
More data for this Ligand-Target Pair |