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SMILES: Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(O)=O)cc2F)c1

InChI Key: InChIKey=CJHIKUXWIQORDE-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 110598   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM110598 (US8614234, 66 | US9725433, 66) Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(O)=O)cc2F)c1 Show InChI InChI=1S/C28H25F2N5O5/c1-16-4-6-20(29)23(11-16)35-28(39)34-22-7-5-18(13-21(22)30)40-19-8-10-31-25(14-19)24-12-17(15-33-24)27(38)32-9-2-3-26(36)37/h4-8,10-15,33H,2-3,9H2,1H3,(H,32,38)(H,36,37)(H2,34,35,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.2	25
Allergan, Inc. US Patent					Assay Description Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30.mu.g of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered S...				US Patent US8614234 (2013) BindingDB Entry DOI: 10.7270/Q20Z71XF
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM110598 (US8614234, 66 | US9725433, 66) Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(O)=O)cc2F)c1 Show InChI InChI=1S/C28H25F2N5O5/c1-16-4-6-20(29)23(11-16)35-28(39)34-22-7-5-18(13-21(22)30)40-19-8-10-31-25(14-19)24-12-17(15-33-24)27(38)32-9-2-3-26(36)37/h4-8,10-15,33H,2-3,9H2,1H3,(H,32,38)(H,36,37)(H2,34,35,39)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...				US Patent US9725433 (2017) BindingDB Entry DOI: 10.7270/Q2ZP4875
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM110598 (US8614234, 66 | US9725433, 66) Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(O)=O)cc2F)c1 Show InChI InChI=1S/C28H25F2N5O5/c1-16-4-6-20(29)23(11-16)35-28(39)34-22-7-5-18(13-21(22)30)40-19-8-10-31-25(14-19)24-12-17(15-33-24)27(38)32-9-2-3-26(36)37/h4-8,10-15,33H,2-3,9H2,1H3,(H,32,38)(H,36,37)(H2,34,35,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...				US Patent US9725433 (2017) BindingDB Entry DOI: 10.7270/Q2ZP4875
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM110598 (US8614234, 66 | US9725433, 66) Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(O)=O)cc2F)c1 Show InChI InChI=1S/C28H25F2N5O5/c1-16-4-6-20(29)23(11-16)35-28(39)34-22-7-5-18(13-21(22)30)40-19-8-10-31-25(14-19)24-12-17(15-33-24)27(38)32-9-2-3-26(36)37/h4-8,10-15,33H,2-3,9H2,1H3,(H,32,38)(H,36,37)(H2,34,35,39)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.2	25
Allergan, Inc. US Patent					Assay Description Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30.mu.g of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered S...				US Patent US8614234 (2013) BindingDB Entry DOI: 10.7270/Q20Z71XF
					More data for this Ligand-Target Pair