BDBM110895 US8614206, 446

SMILES: Cn1ncc(NC(=O)c2nc(sc2N)-c2ccncc2F)c1N1CC[C@H](N)CC(F)(F)C1

InChI Key: InChIKey=JUVHLMKQQBTIQX-JTQLQIEISA-N

Data: 1 KI

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 110895   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110895 (US8614206, 446) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2ccncc2F)c1N1CC[C@H](N)CC(F)(F)C1 |r| Show InChI InChI=1S/C19H21F3N8OS/c1-29-18(30-5-3-10(23)6-19(21,22)9-30)13(8-26-29)27-16(31)14-15(24)32-17(28-14)11-2-4-25-7-12(11)20/h2,4,7-8,10H,3,5-6,9,23-24H2,1H3,(H,27,31)/t10-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.0100	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
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