BDBM11118 (2S)-1-[(2S)-2-amino-3-(4-phenylphenyl)propanoyl]pyrrolidine-2-carbonitrile::4-substituted phenylalanine cyano-(S)-pyrrolidine deriv. 5
SMILES: N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCC[C@H]1C#N
InChI Key: InChIKey=JFHXVIXBGWKRGK-OALUTQOASA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM11118 ((2S)-1-[(2S)-2-amino-3-(4-phenylphenyl)propanoyl]p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 13 | -10.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Johnson & Johnson Pharmaceutical | Assay Description The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r... | Bioorg Med Chem Lett 16: 123-8 (2006) Article DOI: 10.1016/j.bmcl.2005.09.037 BindingDB Entry DOI: 10.7270/Q2S180QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 9 (Homo sapiens (Human)) | BDBM11118 ((2S)-1-[(2S)-2-amino-3-(4-phenylphenyl)propanoyl]p...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of 6xHis-tagged recombinant DPP9 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl... | Bioorg Med Chem 21: 7418-29 (2013) Article DOI: 10.1016/j.bmc.2013.09.048 BindingDB Entry DOI: 10.7270/Q2WS8VPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase VIII (Homo sapiens (Human)) | BDBM11118 ((2S)-1-[(2S)-2-amino-3-(4-phenylphenyl)propanoyl]p...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of 6xHis-tagged recombinant DPP8 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl... | Bioorg Med Chem 21: 7418-29 (2013) Article DOI: 10.1016/j.bmc.2013.09.048 BindingDB Entry DOI: 10.7270/Q2WS8VPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast activation protein alpha (Homo sapiens (Human)) | BDBM11118 ((2S)-1-[(2S)-2-amino-3-(4-phenylphenyl)propanoyl]p...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of 6xHis-tagged recombinant FAP (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Nle-Pro-aminomethylc... | Bioorg Med Chem 21: 7418-29 (2013) Article DOI: 10.1016/j.bmc.2013.09.048 BindingDB Entry DOI: 10.7270/Q2WS8VPZ | |||||||||||
More data for this Ligand-Target Pair |