BDBM112065 US8623889, 63

SMILES: Fc1cc(C#N)c(cc1F)-c1ccc2cc(NC(=O)C3CC3)ncc2c1

InChI Key: InChIKey=KREILUCQUNTRDL-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 112065   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM112065 (US8623889, 63) Show SMILES Fc1cc(C#N)c(cc1F)-c1ccc2cc(NC(=O)C3CC3)ncc2c1 Show InChI InChI=1S/C20H13F2N3O/c21-17-6-14(9-23)16(8-18(17)22)13-4-3-12-7-19(24-10-15(12)5-13)25-20(26)11-1-2-11/h3-8,10-11H,1-2H2,(H,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.0700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Using the following procedure, varying concentration of compounds of the invention were assessed for their ability to inhibit c-Abl enzyme's phos...				US Patent US8623889 (2014) BindingDB Entry DOI: 10.7270/Q2JQ0ZNX
					More data for this Ligand-Target Pair