BDBM112230 US8623889, 228

SMILES: Cc1c(F)c(CO)ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1

InChI Key: InChIKey=GLUGUUHXZDUMOL-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 112230   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM112230 (US8623889, 228) Show SMILES Cc1c(F)c(CO)ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 Show InChI InChI=1S/C20H18FN3O2/c1-11-16(9-22-17(10-25)19(11)21)14-5-4-13-7-18(23-8-15(13)6-14)24-20(26)12-2-3-12/h4-9,12,25H,2-3,10H2,1H3,(H,23,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.0200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Using the following procedure, varying concentration of compounds of the invention were assessed for their ability to inhibit c-Abl enzyme's phos...				US Patent US8623889 (2014) BindingDB Entry DOI: 10.7270/Q2JQ0ZNX
					More data for this Ligand-Target Pair