BDBM112274 US8623889, 272

SMILES: Cc1cc(ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1)[C@H](O)C(F)(F)F

InChI Key: InChIKey=MGAKERYLYVGEOF-IBGZPJMESA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 112274   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM112274 (US8623889, 272) Show SMILES Cc1cc(ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1)[C@H](O)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N3O2/c1-11-6-17(19(28)21(22,23)24)25-10-16(11)14-5-4-13-8-18(26-9-15(13)7-14)27-20(29)12-2-3-12/h4-10,12,19,28H,2-3H2,1H3,(H,26,27,29)/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.0300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Using the following procedure, varying concentration of compounds of the invention were assessed for their ability to inhibit c-Abl enzyme's phos...				US Patent US8623889 (2014) BindingDB Entry DOI: 10.7270/Q2JQ0ZNX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM112274 (US8623889, 272) Show SMILES Cc1cc(ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1)[C@H](O)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N3O2/c1-11-6-17(19(28)21(22,23)24)25-10-16(11)14-5-4-13-8-18(26-9-15(13)7-14)27-20(29)12-2-3-12/h4-10,12,19,28H,2-3H2,1H3,(H,26,27,29)/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Using the following procedure, varying concentration of compounds of the invention were assessed for their ability to inhibit c-Abl enzyme's phos...				US Patent US8623889 (2014) BindingDB Entry DOI: 10.7270/Q2JQ0ZNX
					More data for this Ligand-Target Pair