BDBM112379 US8623889, 378

SMILES: Cc1cccc(F)c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1

InChI Key: InChIKey=GICKHPGUFSHNIL-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 112379   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM112379 (US8623889, 378) Show SMILES Cc1cccc(F)c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 Show InChI InChI=1S/C20H17FN2O/c1-12-3-2-4-17(21)19(12)15-8-7-14-10-18(22-11-16(14)9-15)23-20(24)13-5-6-13/h2-4,7-11,13H,5-6H2,1H3,(H,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.0709	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Using the following procedure, varying concentration of compounds of the invention were assessed for their ability to inhibit c-Abl enzyme's phos...				US Patent US8623889 (2014) BindingDB Entry DOI: 10.7270/Q2JQ0ZNX
					More data for this Ligand-Target Pair