BindingDB PrimarySearch

BDBM11242 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide::med.21724, Compound 76::niclosamide

SMILES: Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O

InChI Key: InChIKey=RJMUSRYZPJIFPJ-UHFFFAOYSA-N

Data: 27 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 11242
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	7.0	25
National Taiwan University					Assay Description The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...				J Med Chem 48: 4469-73 (2005) Article DOI: 10.1021/jm050184y BindingDB Entry DOI: 10.7270/Q20K26S1
National Taiwan University					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Human Genome Research Institute Curated by ChEMBL					Assay Description Inhibition of SARS Co-V 3CL protease				Bioorg Med Chem 17: 5139-45 (2009) Article DOI: 10.1016/j.bmc.2009.05.054 BindingDB Entry DOI: 10.7270/Q28055DF
National Human Genome Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of JAK2				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Src kinase				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Flt3 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of JAK2 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of JNK1 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of PDGFR-beta after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of STAT3 in human HeLa cells after 24 hrs by luciferase reporter gene assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.05E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of EGFR after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.05E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Src kinase				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of FGFR-1 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of VEGFR2 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of LYN after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.78E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of KIT after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Aurora-A after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.94E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Akt1 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.78E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of TIE2 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.75E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of GSK3-beta after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.39E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of PDK1 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Abl1 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of B-Raf after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Erk2 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Institut Pasteur Korea					Assay Description Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 � 104 cells per well in DMEM, supplemented with 2% FBS and 1� ...				Antimicrob Agents Chemother 64: (2020) Article DOI: 10.1128/AAC.00819-20 BindingDB Entry DOI: 10.7270/Q22N54QR
Institut Pasteur Korea					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn					Assay Description This is a review article.				J Med Chem 59: 6595-628 (2016) Article DOI: 10.1021/acs.jmedchem.5b01461 BindingDB Entry DOI: 10.7270/Q2PK0JH1
University of Bonn					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn					Assay Description This is a review article.				Med Res Rev (2020) Article DOI: 10.1002/med.21724 BindingDB Entry DOI: 10.7270/Q2JS9ST6
University of Bonn					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of PKC-alpha after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair