BDBM112472 US8623885, 13
SMILES: C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CNCC(C)c4n3)nc12
InChI Key: InChIKey=CMWZJGXVESUMJY-FKIWDRNQSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-dependent kinase 4 (Homo sapiens (Human)) | BDBM112472 (US8623885, 13) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 31.3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Amgen Inc. US Patent | Assay Description The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat... | US Patent US8623885 (2014) BindingDB Entry DOI: 10.7270/Q2DZ06Z1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM112472 (US8623885, 13) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | 7.6 | n/a |
Amgen Inc. US Patent | Assay Description The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f... | US Patent US8623885 (2014) BindingDB Entry DOI: 10.7270/Q2DZ06Z1 | |||||||||||
More data for this Ligand-Target Pair |