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SMILES: COc1cc(CC=C(c2cc(O)c(OC)cc2O)c2c(OC)cc3OC(CCc3c2O)c2ccc(O)c(O)c2)ccc1O
InChI Key: InChIKey=HDNOPEYAKHYHCG-UHFFFAOYSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dopa decarboxylase (Aromatic L-amino acid decarboxylase), isoform CRA_a (Homo sapiens (Human)) | BDBM112635 ((−)-Euonyquinone C (8) | (+)-Euonyquinone C ...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet  | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | 8.05 | 37 |
Shanghai Center for Systems Biomedicine, School of Pharmacy, and State Key Laboratory of Microbial Metabolism & School of Life Sciences and Biotechnology | Assay Description To the wells of a 384-well polypropylene plate, 1 µL DMSO (control) or test compounds at indicated concentrations were added, followed by the ad... | ACS Chem Biol 9: 897-903 (2014) Article DOI: 10.1021/cb500009r BindingDB Entry DOI: 10.7270/Q2S75F0F | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cystathionine gamma-lyase (Homo sapiens (Human)) | BDBM112635 ((−)-Euonyquinone C (8) | (+)-Euonyquinone C ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Shanghai Center for Systems Biomedicine, School of Pharmacy, and State Key Laboratory of Microbial Metabolism & School of Life Sciences and Biotechnology | Assay Description 500 nM hCSE in optimal buffer (50 mM Hepes, pH 7.0; final concentration) was incubated with compound for 45 min in the 192-tandem-well plate before a... | ACS Chem Biol 9: 897-903 (2014) Article DOI: 10.1021/cb500009r BindingDB Entry DOI: 10.7270/Q2S75F0F | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cystathionine gamma-lyase (Homo sapiens (Human)) | BDBM112635 ((−)-Euonyquinone C (8) | (+)-Euonyquinone C ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Shanghai Center for Systems Biomedicine, School of Pharmacy, and State Key Laboratory of Microbial Metabolism & School of Life Sciences and Biotechnology | Assay Description 500 nM hCSE in optimal buffer (50 mM Hepes, pH 7.0; final concentration) was incubated with compound for 45 min in the 192-tandem-well plate before a... | ACS Chem Biol 9: 897-903 (2014) Article DOI: 10.1021/cb500009r BindingDB Entry DOI: 10.7270/Q2S75F0F | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dopa decarboxylase (Aromatic L-amino acid decarboxylase), isoform CRA_a (Homo sapiens (Human)) | BDBM112635 ((−)-Euonyquinone C (8) | (+)-Euonyquinone C ...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | 8.05 | 37 |
Shanghai Center for Systems Biomedicine, School of Pharmacy, and State Key Laboratory of Microbial Metabolism & School of Life Sciences and Biotechnology | Assay Description To the wells of a 384-well polypropylene plate, 1 µL DMSO (control) or test compounds at indicated concentrations were added, followed by the ad... | ACS Chem Biol 9: 897-903 (2014) Article DOI: 10.1021/cb500009r BindingDB Entry DOI: 10.7270/Q2S75F0F | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
