BindingDB logo
myBDB logout

BDBM113060 US9695194, 1

SMILES: CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccccc1SC

InChI Key: InChIKey=JTQBMTFVGGUDPN-UHFFFAOYSA-N

Data: 7 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 113060   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kallikrein 7


(Homo sapiens (Human))
BDBM113060
PNG
(US9695194, 1)
Show SMILES CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccccc1SC
Show InChI InChI=1S/C18H17NO4S/c1-4-22-15-9-12-13(10-14(15)21-2)19-17(23-18(12)20)11-7-5-6-8-16(11)24-3/h5-10H,4H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
48 -10.4n/an/an/an/an/a7.237



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...


US Patent US9695194 (2017)

More data for this
Ligand-Target Pair
Kallikrein 14


(Homo sapiens (Human))
BDBM113060
PNG
(US9695194, 1)
Show SMILES CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccccc1SC
Show InChI InChI=1S/C18H17NO4S/c1-4-22-15-9-12-13(10-14(15)21-2)19-17(23-18(12)20)11-7-5-6-8-16(11)24-3/h5-10H,4H2,1-3H3
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
100 -9.93n/an/an/an/an/a8.037



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK14, Substrate S-2302 (Chromogenics, cat. no. 820340). KLK14 activity was determined at 37° C. in 0.1 mM Tris, pH ...


US Patent US9695194 (2017)

More data for this
Ligand-Target Pair
Kallikrein 5


(Homo sapiens (Human))
BDBM113060
PNG
(US9695194, 1)
Show SMILES CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccccc1SC
Show InChI InChI=1S/C18H17NO4S/c1-4-22-15-9-12-13(10-14(15)21-2)19-17(23-18(12)20)11-7-5-6-8-16(11)24-3/h5-10H,4H2,1-3H3
PDB
MMDB

KEGG

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
200 -9.50n/an/an/an/an/a8.037



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Recombinant human KLK5, Substrate S-2288 (Chromogenics, cat. no. 820852) KLK5 activity was determined at 37° C. in 0.1 M Tris, pH 8.0,...


US Patent US9695194 (2017)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM113060
PNG
(US9695194, 1)
Show SMILES CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccccc1SC
Show InChI InChI=1S/C18H17NO4S/c1-4-22-15-9-12-13(10-14(15)21-2)19-17(23-18(12)20)11-7-5-6-8-16(11)24-3/h5-10H,4H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4>-7.09n/an/an/an/an/a7.237



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Trypsin, 100 ug (Roche, sequence grade, Mw 23500), Substrate S-2288 (Chromogenics, cat. no. 820852). Trypsin activity was determined at 3...


US Patent US9695194 (2017)

More data for this
Ligand-Target Pair
Chymotrypsin


(Homo sapiens (Human))
BDBM113060
PNG
(US9695194, 1)
Show SMILES CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccccc1SC
Show InChI InChI=1S/C18H17NO4S/c1-4-22-15-9-12-13(10-14(15)21-2)19-17(23-18(12)20)11-7-5-6-8-16(11)24-3/h5-10H,4H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4>-7.09n/an/an/an/an/a7.237



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Chymotrypsin, bovine, 25 ug (Roche, sequence grade), Substrate S-2586 (Chromogenics, cat. no. 82 08 94). Chymotrypsin activity was determi...


US Patent US9695194 (2017)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM113060
PNG
(US9695194, 1)
Show SMILES CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccccc1SC
Show InChI InChI=1S/C18H17NO4S/c1-4-22-15-9-12-13(10-14(15)21-2)19-17(23-18(12)20)11-7-5-6-8-16(11)24-3/h5-10H,4H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4>-7.09n/an/an/an/an/a8.337



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Thrombin (Chromogenics, cat. no. 820712), Substrate S-2288 (Chromogenics, cat. no. 82 08 52). Thrombin activity was determined at 37° ...


US Patent US9695194 (2017)

More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))
BDBM113060
PNG
(US9695194, 1)
Show SMILES CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccccc1SC
Show InChI InChI=1S/C18H17NO4S/c1-4-22-15-9-12-13(10-14(15)21-2)19-17(23-18(12)20)11-7-5-6-8-16(11)24-3/h5-10H,4H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4>-7.09n/an/an/an/an/a7.237



SIXERA PHARMA AB

US Patent


Assay Description
Materials: Cathepsin G, 100 mU (VWR, Calbiochem, cat. no. 219373), Substrate Cathepsin G substrate (VWR, Calbiochem, cat. no. 219407). Cathepsin acti...


US Patent US9695194 (2017)

More data for this
Ligand-Target Pair