BDBM115427 US8637500, 296

SMILES: CC(C)C(=O)N1CCC(CC1)c1nccnc1Oc1ccc(Nc2ccc(C)cn2)cc1

InChI Key: InChIKey=FARYSMHUCWCRNE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 115427   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase Type 10 (PDE10A) (Rattus norvegicus (rat))	BDBM115427 (US8637500, 296) Show SMILES CC(C)C(=O)N1CCC(CC1)c1nccnc1Oc1ccc(Nc2ccc(C)cn2)cc1 Show InChI InChI=1S/C25H29N5O2/c1-17(2)25(31)30-14-10-19(11-15-30)23-24(27-13-12-26-23)32-21-7-5-20(6-8-21)29-22-9-4-18(3)16-28-22/h4-9,12-13,16-17,19H,10-11,14-15H2,1-3H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...				US Patent US8637500 (2014) BindingDB Entry DOI: 10.7270/Q2XP73MV
					More data for this Ligand-Target Pair