BDBM115428 US8637500, 297
SMILES: CCOC(=O)N1CCC(CC1)c1nccnc1Oc1ccc(Nc2ccc(C)cn2)cc1
InChI Key: InChIKey=UJQBUXIQXFHMFK-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase Type 10 (PDE10A) (Rattus norvegicus (rat)) | BDBM115428 (US8637500, 297) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0560 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc. US Patent | Assay Description An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi... | US Patent US8637500 (2014) BindingDB Entry DOI: 10.7270/Q2XP73MV | |||||||||||
More data for this Ligand-Target Pair |