null

SMILES: ONC(=O)C1CCS(=O)(=O)N1c1ccc(cc1)-c1ccccc1

InChI Key: InChIKey=WEJRAOYHTAOVFY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 11545   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM11545 (2-(1,1-biphenyl-4-yl)-N-hydroxyisothiazolidine-3-c...) Show SMILES ONC(=O)C1CCS(=O)(=O)N1c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C16H16N2O4S/c19-16(17-20)15-10-11-23(21,22)18(15)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	667	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...				J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB
					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM11545 (2-(1,1-biphenyl-4-yl)-N-hydroxyisothiazolidine-3-c...) Show SMILES ONC(=O)C1CCS(=O)(=O)N1c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C16H16N2O4S/c19-16(17-20)15-10-11-23(21,22)18(15)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	904	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...				J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM11545 (2-(1,1-biphenyl-4-yl)-N-hydroxyisothiazolidine-3-c...) Show SMILES ONC(=O)C1CCS(=O)(=O)N1c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C16H16N2O4S/c19-16(17-20)15-10-11-23(21,22)18(15)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>2.13E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...				J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM11545 (2-(1,1-biphenyl-4-yl)-N-hydroxyisothiazolidine-3-c...) Show SMILES ONC(=O)C1CCS(=O)(=O)N1c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C16H16N2O4S/c19-16(17-20)15-10-11-23(21,22)18(15)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>4.95E+3	>-7.23	n/a	n/a	n/a	n/a	n/a	7.5	25
Bristol-Myers Squibb Company					Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...				J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB
					More data for this Ligand-Target Pair