null

SMILES: ONC(=O)C1CCS(=O)(=O)N1CCc1ccc(cc1)-c1ccccc1

InChI Key: InChIKey=PIZFUXJESIVHOO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 11547   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM11547 (2-[2-(1,1-biphenyl-4-yl)ethyl]-N-hydroxyisothiazol...) Show SMILES ONC(=O)C1CCS(=O)(=O)N1CCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C18H20N2O4S/c21-18(19-22)17-11-13-25(23,24)20(17)12-10-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17,22H,10-13H2,(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	433	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...				J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM11547 (2-[2-(1,1-biphenyl-4-yl)ethyl]-N-hydroxyisothiazol...) Show SMILES ONC(=O)C1CCS(=O)(=O)N1CCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C18H20N2O4S/c21-18(19-22)17-11-13-25(23,24)20(17)12-10-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17,22H,10-13H2,(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	702	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...				J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB
					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM11547 (2-[2-(1,1-biphenyl-4-yl)ethyl]-N-hydroxyisothiazol...) Show SMILES ONC(=O)C1CCS(=O)(=O)N1CCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C18H20N2O4S/c21-18(19-22)17-11-13-25(23,24)20(17)12-10-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17,22H,10-13H2,(H,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.06E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...				J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM11547 (2-[2-(1,1-biphenyl-4-yl)ethyl]-N-hydroxyisothiazol...) Show SMILES ONC(=O)C1CCS(=O)(=O)N1CCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C18H20N2O4S/c21-18(19-22)17-11-13-25(23,24)20(17)12-10-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17,22H,10-13H2,(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>4.95E+3	>-7.23	n/a	n/a	n/a	n/a	n/a	7.5	25
Bristol-Myers Squibb Company					Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...				J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB
					More data for this Ligand-Target Pair