BDBM11703 (2S)-Cyanopyrrolidine analogue 18g::1-{4-[3-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)propanoyl]piperazin-1-yl}-1,6-dihydropyridine-3-carbonitrile

SMILES: O=C(CNCCC(=O)N1CCN(CC1)N1CC=CC(=C1)C#N)N1CCC[C@H]1C#N

InChI Key: InChIKey=GUSVKVKGPJDNCE-SFHVURJKSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 11703   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM11703 ((2S)-Cyanopyrrolidine analogue 18g | 1-{4-[3-({2-[...) Show SMILES O=C(CNCCC(=O)N1CCN(CC1)N1CC=CC(=C1)C#N)N1CCC[C@H]1C#N |r,c:17,19| Show InChI InChI=1S/C20H27N7O2/c21-13-17-3-1-7-26(16-17)25-11-9-24(10-12-25)19(28)5-6-23-15-20(29)27-8-2-4-18(27)14-22/h1,3,16,18,23H,2,4-12,15H2/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	629	n/a	n/a	n/a	n/a	8.0	37
National Health Research Institutes					Assay Description The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...				J Med Chem 49: 373-80 (2006) Article DOI: 10.1021/jm0507781 BindingDB Entry DOI: 10.7270/Q28W3BJH
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human))	BDBM11703 ((2S)-Cyanopyrrolidine analogue 18g | 1-{4-[3-({2-[...) Show SMILES O=C(CNCCC(=O)N1CCN(CC1)N1CC=CC(=C1)C#N)N1CCC[C@H]1C#N |r,c:17,19| Show InChI InChI=1S/C20H27N7O2/c21-13-17-3-1-7-26(16-17)25-11-9-24(10-12-25)19(28)5-6-23-15-20(29)27-8-2-4-18(27)14-22/h1,3,16,18,23H,2,4-12,15H2/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.81E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes					Assay Description The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...				J Med Chem 49: 373-80 (2006) Article DOI: 10.1021/jm0507781 BindingDB Entry DOI: 10.7270/Q28W3BJH
					More data for this Ligand-Target Pair
Dipeptidyl peptidase VIII (Homo sapiens (Human))	BDBM11703 ((2S)-Cyanopyrrolidine analogue 18g | 1-{4-[3-({2-[...) Show SMILES O=C(CNCCC(=O)N1CCN(CC1)N1CC=CC(=C1)C#N)N1CCC[C@H]1C#N |r,c:17,19| Show InChI InChI=1S/C20H27N7O2/c21-13-17-3-1-7-26(16-17)25-11-9-24(10-12-25)19(28)5-6-23-15-20(29)27-8-2-4-18(27)14-22/h1,3,16,18,23H,2,4-12,15H2/t18-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes					Assay Description The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...				J Med Chem 49: 373-80 (2006) Article DOI: 10.1021/jm0507781 BindingDB Entry DOI: 10.7270/Q28W3BJH
					More data for this Ligand-Target Pair