BDBM11711 (2S)-Cyanopyrrolidine analogue 18o::3-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-N-(2-phenylethyl)propanamide::3-[2-(2-Cyano-(S)-pyrrolidin-1-yl)-2-oxoethylamino]-N-phenethylpropionamide::CHEMBL201544
SMILES: O=C(CCNCC(=O)N1CCC[C@H]1C#N)NCCc1ccccc1
InChI Key: InChIKey=HBNLROSMYAVTTQ-INIZCTEOSA-N
Data: 7 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM11711 ((2S)-Cyanopyrrolidine analogue 18o | 3-({2-[(2S)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 564 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes | Assay Description The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro... | J Med Chem 49: 373-80 (2006) Article DOI: 10.1021/jm0507781 BindingDB Entry DOI: 10.7270/Q28W3BJH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase VIII (Homo sapiens (Human)) | BDBM11711 ((2S)-Cyanopyrrolidine analogue 18o | 3-({2-[(2S)-2...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes | Assay Description The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro... | J Med Chem 49: 373-80 (2006) Article DOI: 10.1021/jm0507781 BindingDB Entry DOI: 10.7270/Q28W3BJH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human)) | BDBM11711 ((2S)-Cyanopyrrolidine analogue 18o | 3-({2-[(2S)-2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes | Assay Description The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro... | J Med Chem 49: 373-80 (2006) Article DOI: 10.1021/jm0507781 BindingDB Entry DOI: 10.7270/Q28W3BJH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM11711 ((2S)-Cyanopyrrolidine analogue 18o | 3-({2-[(2S)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 564 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes Curated by ChEMBL | Assay Description In vitro inhibition of DPP-4 | Bioorg Med Chem Lett 17: 1274-9 (2007) Article DOI: 10.1016/j.bmcl.2006.12.019 BindingDB Entry DOI: 10.7270/Q23T9GV7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase VIII (Homo sapiens (Human)) | BDBM11711 ((2S)-Cyanopyrrolidine analogue 18o | 3-({2-[(2S)-2...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes Curated by ChEMBL | Assay Description In vitro inhibition of DPP-8 | Bioorg Med Chem Lett 17: 1274-9 (2007) Article DOI: 10.1016/j.bmcl.2006.12.019 BindingDB Entry DOI: 10.7270/Q23T9GV7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human)) | BDBM11711 ((2S)-Cyanopyrrolidine analogue 18o | 3-({2-[(2S)-2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes Curated by ChEMBL | Assay Description In vitro inhibition of DPP-II | Bioorg Med Chem Lett 17: 1274-9 (2007) Article DOI: 10.1016/j.bmcl.2006.12.019 BindingDB Entry DOI: 10.7270/Q23T9GV7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast activation protein alpha (Homo sapiens (Human)) | BDBM11711 ((2S)-Cyanopyrrolidine analogue 18o | 3-({2-[(2S)-2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes Curated by ChEMBL | Assay Description In vitro inhibition of FAP, seprase | Bioorg Med Chem Lett 17: 1274-9 (2007) Article DOI: 10.1016/j.bmcl.2006.12.019 BindingDB Entry DOI: 10.7270/Q23T9GV7 | |||||||||||
More data for this Ligand-Target Pair |