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SMILES: Cc1ccc(cc1Nc1ncnc2cnc(nc12)N1CCOCC1)C(=O)Nc1cc(ccn1)C(F)(F)F

InChI Key: InChIKey=LYQGPLIHPFJRPG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 117641   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase B-raf [V600E]


(Homo sapiens (Human))		BDBM117641
PNG
(US8653087, III-321)
Show SMILES Cc1ccc(cc1Nc1ncnc2cnc(nc12)N1CCOCC1)C(=O)Nc1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C24H21F3N8O2/c1-14-2-3-15(22(36)33-19-11-16(4-5-28-19)24(25,26)27)10-17(14)32-21-20-18(30-13-31-21)12-29-23(34-20)35-6-8-37-9-7-35/h2-5,10-13H,6-9H2,1H3,(H,28,33,36)(H,30,31,32)
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Similars
US Patent
n/an/a<1n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The final concentration of DMSO is 5%. 10 μL of the B-Raf (V600E)-kinase solution are pipetted in (containing 0.5 ng B-Raf (V600E)-kinase in 20 ...

US Patent US8653087 (2014)


BindingDB Entry DOI: 10.7270/Q2CR5S1G
More data for this
Ligand-Target Pair