BDBM117659 US8653087, III-339

SMILES: Cc1ccc(cc1Nc1ncnc2cnc(nc12)N1CCNCC1)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key: InChIKey=AMAWUBIRLFBJGS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 117659   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
B-RAF V600E (Homo sapiens (Human))	BDBM117659 (US8653087, III-339) Show SMILES Cc1ccc(cc1Nc1ncnc2cnc(nc12)N1CCNCC1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C25H23F3N8O/c1-15-5-6-16(23(37)33-18-4-2-3-17(12-18)25(26,27)28)11-19(15)34-22-21-20(31-14-32-22)13-30-24(35-21)36-9-7-29-8-10-36/h2-6,11-14,29H,7-10H2,1H3,(H,33,37)(H,31,32,34)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The final concentration of DMSO is 5%. 10 μL of the B-Raf (V600E)-kinase solution are pipetted in (containing 0.5 ng B-Raf (V600E)-kinase in 20 ...				US Patent US8653087 (2014) BindingDB Entry DOI: 10.7270/Q2CR5S1G
					More data for this Ligand-Target Pair