BDBM117669 US8653087, III-349

SMILES: Cc1ccc(cc1Nc1ncnc2cnc(NC3CCOC3)nc12)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key: InChIKey=ZLNDXCLRQQYJFS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 117669   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
B-RAF V600E (Homo sapiens (Human))	BDBM117669 (US8653087, III-349) Show SMILES Cc1ccc(cc1Nc1ncnc2cnc(NC3CCOC3)nc12)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C25H22F3N7O2/c1-14-5-6-15(23(36)32-17-4-2-3-16(10-17)25(26,27)28)9-19(14)34-22-21-20(30-13-31-22)11-29-24(35-21)33-18-7-8-37-12-18/h2-6,9-11,13,18H,7-8,12H2,1H3,(H,32,36)(H,29,33,35)(H,30,31,34)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The final concentration of DMSO is 5%. 10 μL of the B-Raf (V600E)-kinase solution are pipetted in (containing 0.5 ng B-Raf (V600E)-kinase in 20 ...				US Patent US8653087 (2014) BindingDB Entry DOI: 10.7270/Q2CR5S1G
					More data for this Ligand-Target Pair