BDBM117673 US8653087, III-353

SMILES: Cc1ccc(cc1Nc1ncnc2cnc(NC3CCOC3)nc12)C(=O)Nc1cc(n[nH]1)C(C)(C)C

InChI Key: InChIKey=LAXMGBJPXBBLCA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 117673   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
B-RAF V600E (Homo sapiens (Human))	BDBM117673 (US8653087, III-353) Show SMILES Cc1ccc(cc1Nc1ncnc2cnc(NC3CCOC3)nc12)C(=O)Nc1cc(n[nH]1)C(C)(C)C Show InChI InChI=1S/C25H29N9O2/c1-14-5-6-15(23(35)31-20-10-19(33-34-20)25(2,3)4)9-17(14)30-22-21-18(27-13-28-22)11-26-24(32-21)29-16-7-8-36-12-16/h5-6,9-11,13,16H,7-8,12H2,1-4H3,(H,26,29,32)(H,27,28,30)(H2,31,33,34,35)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The final concentration of DMSO is 5%. 10 μL of the B-Raf (V600E)-kinase solution are pipetted in (containing 0.5 ng B-Raf (V600E)-kinase in 20 ...				US Patent US8653087 (2014) BindingDB Entry DOI: 10.7270/Q2CR5S1G
					More data for this Ligand-Target Pair