BDBM117683 US8653087, III-363

SMILES: Cc1ccc(cc1Nc1ncnc2cnc(nc12)N1CCC[C@H]1CO)C(=O)Nc1cc(on1)C(C)(C)C

InChI Key: InChIKey=JWCPKPOZCIKSJI-KRWDZBQOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 117683   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
B-RAF V600E (Homo sapiens (Human))	BDBM117683 (US8653087, III-363) Show SMILES Cc1ccc(cc1Nc1ncnc2cnc(nc12)N1CCC[C@H]1CO)C(=O)Nc1cc(on1)C(C)(C)C |r| Show InChI InChI=1S/C26H30N8O3/c1-15-7-8-16(24(36)31-21-11-20(37-33-21)26(2,3)4)10-18(15)30-23-22-19(28-14-29-23)12-27-25(32-22)34-9-5-6-17(34)13-35/h7-8,10-12,14,17,35H,5-6,9,13H2,1-4H3,(H,28,29,30)(H,31,33,36)/t17-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The final concentration of DMSO is 5%. 10 μL of the B-Raf (V600E)-kinase solution are pipetted in (containing 0.5 ng B-Raf (V600E)-kinase in 20 ...				US Patent US8653087 (2014) BindingDB Entry DOI: 10.7270/Q2CR5S1G
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