null
SMILES: COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(nc34)N3CCN(CC4CCN(C)CC4)CC3)c2)cc1C(F)(F)F
InChI Key: InChIKey=UPKYYVVGGHRRGU-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM117739 (US8653087, III-419 | US8653087, III-562) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description The final concentration of DMSO is 5%. 10 μL of the B-Raf (V600E)-kinase solution are pipetted in (containing 0.5 ng B-Raf (V600E)-kinase in 20 ... | US Patent US8653087 (2014) BindingDB Entry DOI: 10.7270/Q2CR5S1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM117739 (US8653087, III-419 | US8653087, III-562) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description The final concentration of DMSO is 5%. 10 μL of the B-Raf (V600E)-kinase solution are pipetted in (containing 0.5 ng B-Raf (V600E)-kinase in 20 ... | US Patent US8653087 (2014) BindingDB Entry DOI: 10.7270/Q2CR5S1G | |||||||||||
More data for this Ligand-Target Pair |