BDBM11819 (3R,4R)-N-{4-[4-(2-hydroxy-5-piperidin-1-ylbenzoyl)benzoylamino]azepan-3-yl}isonicotinamide hydrochloride::N-[(3R,4R)-4-[(4-{[2-hydroxy-5-(piperidin-1-yl)phenyl]carbonyl}benzene)amido]azepan-3-yl]pyridine-4-carboxamide hydrochloride::Protein Kinase B-Selective Inhibitor 3
SMILES: Oc1ccc(cc1C(=O)c1ccc(cc1)C(=O)N[C@@H]1CCCNC[C@H]1NC(=O)c1ccncc1)N1CCCCC1
InChI Key: InChIKey=VXVVBHZWCMDJPJ-KAYWLYCHSA-N
Data: 2 IC50
PDB links: 1 PDB ID matches this monomer. 2 PDB IDs contain this monomer as substructures. 2 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine)) | BDBM11819 ((3R,4R)-N-{4-[4-(2-hydroxy-5-piperidin-1-ylbenzoyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Max-Planck-Institut fuer Biochemie | Assay Description In this assay, a fluorescent phosphopeptide tracer and the nonfluorescent phosphopeptides generated during a PKA reaction compete for binding to an a... | J Med Chem 48: 163-70 (2005) Article DOI: 10.1021/jm049701n BindingDB Entry DOI: 10.7270/Q21C1V3S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM11819 ((3R,4R)-N-{4-[4-(2-hydroxy-5-piperidin-1-ylbenzoyl...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Max-Planck-Institut fuer Biochemie | Assay Description An ELISA-based assay has been developed for the serine/threonine kinase, PKB-alpha. The assay utilizes an N-terminally biotinylated substrate peptide... | J Med Chem 48: 163-70 (2005) Article DOI: 10.1021/jm049701n BindingDB Entry DOI: 10.7270/Q21C1V3S | |||||||||||
More data for this Ligand-Target Pair |