BDBM11833 3-[2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol-10-yl]-4-(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::BIM-10

SMILES: NCC1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1c[nH]c3ccccc13)c1ccccc21

InChI Key: InChIKey=WCPRHIKZZFXHSD-UHFFFAOYSA-N

Data: 1 Kd  1 ITC

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 11833   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM11833 (3-[2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol-...) Show SMILES NCC1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1c[nH]c3ccccc13)c1ccccc21 |t:10| Show InChI InChI=1S/C25H22N4O2/c26-12-14-9-10-29-19-8-4-2-6-16(19)21(20(29)11-14)23-22(24(30)28-25(23)31)17-13-27-18-7-3-1-5-15(17)18/h1-8,13-14,27H,9-12,26H2,(H,28,30,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a
Oxford University Curated by ChEMBL					Assay Description Binding affinity to non phosphorylated PIM1				J Med Chem 48: 7604-14 (2005) Article DOI: 10.1021/jm0504858 BindingDB Entry DOI: 10.7270/Q2Q52R4H
					More data for this Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 11833

Cell (A)	Syringe (B)	Cell Links	Syringe Links	Cell + Syr Links	ΔG° kcal/mole	-TΔS° kcal/mole	ΔH° kcal/mole	log K	pH	Temp °C
BDBM11833 (3-[2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol-...)	Serine/threonine-protein kinase PIM (Homo sapiens (Human))	PC cid PC sid	DrugBank GoogleScholar KEGG PDB		-9.19	-3.58	-5.59	7.14	7.5	10
	Oxford University				J Med Chem 48: 7604-14 (2005)