BDBM11917 (1S,3S,5S)-2-[(1S,2S,5R)-3-azabicyclo[3.1.0]hexan-2-ylcarbonyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile::substituted diprolyl nitrile 10

SMILES: O=C([C@H]1NC[C@@H]2C[C@H]12)N1[C@H]2C[C@H]2C[C@H]1C#N

InChI Key: InChIKey=VBOULAMEOZIRIN-UPLHKLGHSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 11917   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase IV (Sus scrofa (pig))	BDBM11917 ((1S,3S,5S)-2-[(1S,2S,5R)-3-azabicyclo[3.1.0]hexan-...) Show SMILES O=C([C@H]1NC[C@@H]2C[C@H]12)N1[C@H]2C[C@H]2C[C@H]1C#N |r| Show InChI InChI=1S/C12H15N3O/c13-4-8-1-6-3-10(6)15(8)12(16)11-9-2-7(9)5-14-11/h6-11,14H,1-3,5H2/t6-,7+,8+,9+,10+,11+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	52	-9.83	n/a	n/a	n/a	n/a	n/a	7.4	22
Bristol-Myers Squibb Pharmaceutical Research Institute					Assay Description Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...				Bioorg Med Chem Lett 15: 3992-5 (2005) Article DOI: 10.1016/j.bmcl.2005.06.043 BindingDB Entry DOI: 10.7270/Q2CN7259
					More data for this Ligand-Target Pair