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SMILES: CN1CCC(COc2c(-c3cccs3)c(=O)[nH]c3ccc(cc23)C#Cc2cccnc2)CC1

InChI Key: InChIKey=CTIHNIAVBYMPQC-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 119682   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM119682
PNG
(US8680116, 1-23)
Show SMILES CN1CCC(COc2c(-c3cccs3)c(=O)[nH]c3ccc(cc23)C#Cc2cccnc2)CC1
Show InChI InChI=1S/C27H25N3O2S/c1-30-13-10-21(11-14-30)18-32-26-22-16-19(6-7-20-4-2-12-28-17-20)8-9-23(22)29-27(31)25(26)24-5-3-15-33-24/h2-5,8-9,12,15-17,21H,10-11,13-14,18H2,1H3,(H,29,31)
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem

Similars
US Patent
 62n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...

US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair