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SMILES: Cc1nc(\C=C\c2c(nnn2C)-c2ccccn2)sc1C(=O)NC1CCOCC1

InChI Key: InChIKey=DFGIKMAFZLSMDI-VOTSOKGWSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120154   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gamma-aminobutyric acid receptor subunit alpha-5


(Homo sapiens (Human))		BDBM120154
PNG
(US8697696, 11)
Show SMILES Cc1nc(\C=C\c2c(nnn2C)-c2ccccn2)sc1C(=O)NC1CCOCC1
Show InChI InChI=1S/C20H22N6O2S/c1-13-19(20(27)23-14-8-11-28-12-9-14)29-17(22-13)7-6-16-18(24-25-26(16)2)15-5-3-4-10-21-15/h3-7,10,14H,8-9,11-12H2,1-2H3,(H,23,27)/b7-6+
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Similars
US Patent
 12.7 -10.0n/an/an/an/an/a7.54



Roche Palo Alto LLC

US Patent


Assay Description
Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell membranes, [3H]flumazenil at a conc...

US Patent US8697696 (2014)


BindingDB Entry DOI: 10.7270/Q2DB80HJ
More data for this
Ligand-Target Pair