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BDBM12035 3-(4-chlorophenyl)-1-{4-[(2E)-3-(2,4-dichlorophenyl)prop-2-enoyl]phenyl}urea::Phenylurenyl Chalcone deriv. 25

SMILES: Clc1ccc(NC(=O)Nc2ccc(cc2)C(=O)\C=C\c2ccc(Cl)cc2Cl)cc1

InChI Key: InChIKey=SUEOSKDNYVFGRN-UUILKARUSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 12035   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Falcipain-2


(Plasmodium falciparum)
BDBM12035
PNG
(3-(4-chlorophenyl)-1-{4-[(2E)-3-(2,4-dichloropheny...)
Show SMILES Clc1ccc(NC(=O)Nc2ccc(cc2)C(=O)\C=C\c2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C22H15Cl3N2O2/c23-16-6-10-19(11-7-16)27-22(29)26-18-8-2-15(3-9-18)21(28)12-4-14-1-5-17(24)13-20(14)25/h1-13H,(H2,26,27,29)/b12-4+
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/a5.522



Universidad Central de Venezuela



Assay Description
The substrate peptide terminating in AMC is processed by falcipain-2 with or without inhibitors, and the accumulation of AMC was monitored in a Labsy...


J Med Chem 48: 3654-8 (2005)

More data for this
Ligand-Target Pair