BDBM12038 3-(4-chlorophenyl)-1-{4-[(2E)-3-phenylprop-2-enoyl]phenyl}urea::Phenylurenyl Chalcone deriv. 28

SMILES: Clc1ccc(NC(=O)Nc2ccc(cc2)C(=O)\C=C\c2ccccc2)cc1

InChI Key: InChIKey=BFZGOTURPZHLCU-GIDUJCDVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 12038   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Falcipain-2 (Plasmodium falciparum)	BDBM12038 (3-(4-chlorophenyl)-1-{4-[(2E)-3-phenylprop-2-enoyl...) Show SMILES Clc1ccc(NC(=O)Nc2ccc(cc2)C(=O)\C=C\c2ccccc2)cc1 Show InChI InChI=1S/C22H17ClN2O2/c23-18-9-13-20(14-10-18)25-22(27)24-19-11-7-17(8-12-19)21(26)15-6-16-4-2-1-3-5-16/h1-15H,(H2,24,25,27)/b15-6+	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	5.5	22
Universidad Central de Venezuela					Assay Description The substrate peptide terminating in AMC is processed by falcipain-2 with or without inhibitors, and the accumulation of AMC was monitored in a Labsy...				J Med Chem 48: 3654-8 (2005) Article DOI: 10.1021/jm058208o BindingDB Entry DOI: 10.7270/Q2GF0RRD
					More data for this Ligand-Target Pair