BDBM120743 US8703767, 3
SMILES: Fc1cc(Nc2nc(-c3cccc(NC(=O)C=C)c3)c3c[nH]nc3n2)ccc1N1CCOCC1
InChI Key: InChIKey=RDSCJUMHYIIQEB-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM120743 (US8703767, 3) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | 25 |
University of Utah Research Foundation US Patent | Assay Description Activity of compounds was routinely confirmed using a secondary assay as described herein. The secondary assay was a time resolved-FRET kinase assay.... | US Patent US8703767 (2014) BindingDB Entry DOI: 10.7270/Q23X85BF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM120743 (US8703767, 3) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | 25 |
University of Utah Research Foundation US Patent | Assay Description The primary assay for compound inhibitory activity was the ADP generation assay described herein. Test compounds were diluted to desired concentratio... | US Patent US8703767 (2014) BindingDB Entry DOI: 10.7270/Q23X85BF | |||||||||||
More data for this Ligand-Target Pair |