BDBM120744 US8703767, 4

SMILES: Clc1nc(-c2cccc(NC(=O)C=C)c2)c2c[nH]nc2n1

InChI Key: InChIKey=MOBPAJVDZWZBRJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 120744   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM120744 (US8703767, 4) Show SMILES Clc1nc(-c2cccc(NC(=O)C=C)c2)c2c[nH]nc2n1 Show InChI InChI=1S/C14H10ClN5O/c1-2-11(21)17-9-5-3-4-8(6-9)12-10-7-16-20-13(10)19-14(15)18-12/h2-7H,1H2,(H,17,21)(H,16,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.77E+3	n/a	n/a	n/a	n/a	n/a	25
University of Utah Research Foundation US Patent					Assay Description Activity of compounds was routinely confirmed using a secondary assay as described herein. The secondary assay was a time resolved-FRET kinase assay....				US Patent US8703767 (2014) BindingDB Entry DOI: 10.7270/Q23X85BF
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM120744 (US8703767, 4) Show SMILES Clc1nc(-c2cccc(NC(=O)C=C)c2)c2c[nH]nc2n1 Show InChI InChI=1S/C14H10ClN5O/c1-2-11(21)17-9-5-3-4-8(6-9)12-10-7-16-20-13(10)19-14(15)18-12/h2-7H,1H2,(H,17,21)(H,16,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	263	n/a	n/a	n/a	n/a	n/a	25
University of Utah Research Foundation US Patent					Assay Description The primary assay for compound inhibitory activity was the ADP generation assay described herein. Test compounds were diluted to desired concentratio...				US Patent US8703767 (2014) BindingDB Entry DOI: 10.7270/Q23X85BF
					More data for this Ligand-Target Pair