BDBM120876 US8716287, 9

SMILES: Fc1cccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)c1

InChI Key: InChIKey=KHWMZCBTJIUUHL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120876   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM120876 (US8716287, 9) Show SMILES Fc1cccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)c1 Show InChI InChI=1S/C21H18ClFN6O/c22-19-9-17(28-21(30)29-20-13-26-18(10-24)12-27-20)5-4-15(19)6-7-25-11-14-2-1-3-16(23)8-14/h1-5,8-9,12-13,25H,6-7,11H2,(H2,27,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	n/a
Sentinel Oncology Limited US Patent					Assay Description The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...				US Patent US8716287 (2014) BindingDB Entry DOI: 10.7270/Q2TD9W0C
					More data for this Ligand-Target Pair