BDBM120922 US8716287, 55

SMILES: COc1ccccc1CNCCc1cc(OC)c(NC(=O)Nc2cnc(cn2)C#N)cc1Cl

InChI Key: InChIKey=WZUKOFIYGZRAIC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120922   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM120922 (US8716287, 55) Show SMILES COc1ccccc1CNCCc1cc(OC)c(NC(=O)Nc2cnc(cn2)C#N)cc1Cl Show InChI InChI=1S/C23H23ClN6O3/c1-32-20-6-4-3-5-16(20)12-26-8-7-15-9-21(33-2)19(10-18(15)24)29-23(31)30-22-14-27-17(11-25)13-28-22/h3-6,9-10,13-14,26H,7-8,12H2,1-2H3,(H2,28,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.480	n/a	n/a	n/a	n/a	7.5	n/a
Sentinel Oncology Limited US Patent					Assay Description The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...				US Patent US8716287 (2014) BindingDB Entry DOI: 10.7270/Q2TD9W0C
					More data for this Ligand-Target Pair