BDBM120932 US8716287, 65

SMILES: COc1cccc(c1)[C@H](C)NCCc1cc(OC)c(NC(=O)Nc2cnc(cn2)C#N)cc1Cl

InChI Key: InChIKey=OHJPEBBDXIGQBJ-HNNXBMFYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120932   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM120932 (US8716287, 65) Show SMILES COc1cccc(c1)[C@H](C)NCCc1cc(OC)c(NC(=O)Nc2cnc(cn2)C#N)cc1Cl |r| Show InChI InChI=1S/C24H25ClN6O3/c1-15(16-5-4-6-19(9-16)33-2)27-8-7-17-10-22(34-3)21(11-20(17)25)30-24(32)31-23-14-28-18(12-26)13-29-23/h4-6,9-11,13-15,27H,7-8H2,1-3H3,(H2,29,30,31,32)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.730	n/a	n/a	n/a	n/a	7.5	n/a
Sentinel Oncology Limited US Patent					Assay Description The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...				US Patent US8716287 (2014) BindingDB Entry DOI: 10.7270/Q2TD9W0C
					More data for this Ligand-Target Pair