BDBM120983 US8716285, 40
SMILES: ONC(=O)c1ccc2CCC(Cc2c1)NS(=O)(=O)c1cccc(F)c1
InChI Key: InChIKey=ZACXBNMJKYCGEK-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 6 (Homo sapiens (Human)) | BDBM120983 (US8716285, 40) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 990 | n/a | n/a | n/a | n/a |
Roche Pharmaceutical Research and Early Development Curated by ChEMBL | Assay Description Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay | J Med Chem 57: 8026-34 (2014) Article DOI: 10.1021/jm5008962 BindingDB Entry DOI: 10.7270/Q29C700V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM120983 (US8716285, 40) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description Compounds were tested for their ability to inhibit histone deacetylase 8 using an in vitro deacetylation assay. In a detailed procedure, 8 μl o... | US Patent US8716285 (2014) BindingDB Entry DOI: 10.7270/Q2K072XG | |||||||||||
More data for this Ligand-Target Pair |