BDBM121393 US8722877, 18
SMILES: CC(C)N(CCCNC(=O)Nc1nc2ccc(cc2[nH]1)C(C)(C)C)CC1O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12
InChI Key: InChIKey=JHPZZWSSEJCBRJ-KYSCMSHESA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase, H3 lysine-79 specific (Homo sapiens (Human)) | BDBM121393 (US8722877, 18) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Epizyme, Inc. US Patent | Assay Description Compound was serially diluted 3 fold in DMSO for 10 points and 1 μl was plated in a 384 well microtiter plate. Positive control (100% inhibition... | US Patent US8722877 (2014) BindingDB Entry DOI: 10.7270/Q2X63KKV | |||||||||||
More data for this Ligand-Target Pair |