BDBM12250 AZD0530 analogue 28::N-(5-Chloro-1,3-benzodioxol-4-yl)-7-(2-fluoroethoxy)-5-[(1-methylpiperidin-4-yl)oxy]quinazolin-4-amine::N-(5-chloro-2H-1,3-benzodioxol-4-yl)-7-(2-fluoroethoxy)-5-[(1-methylpiperidin-4-yl)oxy]quinazolin-4-amine

SMILES: CN1CCC(CC1)Oc1cc(OCCF)cc2ncnc(Nc3c4OCOc4ccc3Cl)c12

InChI Key: InChIKey=KCOQHIMIYASHED-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 12250   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM12250 (AZD0530 analogue 28 | N-(5-Chloro-1,3-benzodioxol-...) Show SMILES CN1CCC(CC1)Oc1cc(OCCF)cc2ncnc(Nc3c4OCOc4ccc3Cl)c12 Show InChI InChI=1S/C23H24ClFN4O4/c1-29-7-4-14(5-8-29)33-19-11-15(30-9-6-25)10-17-20(19)23(27-12-26-17)28-21-16(24)2-3-18-22(21)32-13-31-18/h2-3,10-12,14H,4-9,13H2,1H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...				J Med Chem 49: 6465-88 (2006) Article DOI: 10.1021/jm060434q BindingDB Entry DOI: 10.7270/Q2J67F5X
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM12250 (AZD0530 analogue 28 | N-(5-Chloro-1,3-benzodioxol-...) Show SMILES CN1CCC(CC1)Oc1cc(OCCF)cc2ncnc(Nc3c4OCOc4ccc3Cl)c12 Show InChI InChI=1S/C23H24ClFN4O4/c1-29-7-4-14(5-8-29)33-19-11-15(30-9-6-25)10-17-20(19)23(27-12-26-17)28-21-16(24)2-3-18-22(21)32-13-31-18/h2-3,10-12,14H,4-9,13H2,1H3,(H,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...				J Med Chem 49: 6465-88 (2006) Article DOI: 10.1021/jm060434q BindingDB Entry DOI: 10.7270/Q2J67F5X
					More data for this Ligand-Target Pair