null
SMILES: CC1(C)OCC(N)=N[C@](C)(c2cc(N[C@H]3CCc4cc(cnc34)C#N)c(F)cc2F)C1(F)F
InChI Key: InChIKey=ZXPMSLQQIPEYLP-HTAPYJJXSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 2 (Homo sapiens (Human)) | BDBM123875 (US8748418, 20) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 170 | n/a | n/a | n/a | n/a | 4.5 | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description The FRET assay was performed essentially as described in Gruninger-Leitch et al., Journal of Biological Chemistry (2002) 277(7) 4687-93 (Substrate an... | US Patent US8748418 (2014) BindingDB Entry DOI: 10.7270/Q2C53JJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM123875 (US8748418, 20) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | 4.5 | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description The FRET assay was performed essentially as described in Gruninger-Leitch et al., Journal of Biological Chemistry (2002) 277(7) 4687-93 (Substrate an... | US Patent US8748418 (2014) BindingDB Entry DOI: 10.7270/Q2C53JJP | |||||||||||
More data for this Ligand-Target Pair |