BDBM124241 N,N'-([1,1'-biphenyl]-4,4'-diyl)bis(1-(furan-2-carbonyl)piperidine-4-carboxamide) (15)

SMILES: O=C(Nc1ccc(cc1)-c1ccc(NC(=O)C2CCN(CC2)C(=O)c2ccco2)cc1)C1CCN(CC1)C(=O)c1ccco1

InChI Key: InChIKey=UKYOUOAVIWGVLO-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 124241   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM124241 (N,N'-([1,1'-biphenyl]-4,4'-diyl)bis(1-...) Show SMILES O=C(Nc1ccc(cc1)-c1ccc(NC(=O)C2CCN(CC2)C(=O)c2ccco2)cc1)C1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C34H34N4O6/c39-31(25-13-17-37(18-14-25)33(41)29-3-1-21-43-29)35-27-9-5-23(6-10-27)24-7-11-28(12-8-24)36-32(40)26-15-19-38(20-16-26)34(42)30-4-2-22-44-30/h1-12,21-22,25-26H,13-20H2,(H,35,39)(H,36,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jiangnan University					Assay Description IC50 values were determined by pNPP assay.				Bioorg Med Chem Lett 24: 1889-94 (2014) Article DOI: 10.1016/j.bmcl.2014.03.015 BindingDB Entry DOI: 10.7270/Q2PC3122
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM124241 (N,N'-([1,1'-biphenyl]-4,4'-diyl)bis(1-...) Show SMILES O=C(Nc1ccc(cc1)-c1ccc(NC(=O)C2CCN(CC2)C(=O)c2ccco2)cc1)C1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C34H34N4O6/c39-31(25-13-17-37(18-14-25)33(41)29-3-1-21-43-29)35-27-9-5-23(6-10-27)24-7-11-28(12-8-24)36-32(40)26-15-19-38(20-16-26)34(42)30-4-2-22-44-30/h1-12,21-22,25-26H,13-20H2,(H,35,39)(H,36,40)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	1.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jiangnan University Curated by ChEMBL					Assay Description Inhibition of GST-tagged TCPTP (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assay				Bioorg Med Chem Lett 30: (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM124241 (N,N'-([1,1'-biphenyl]-4,4'-diyl)bis(1-...) Show SMILES O=C(Nc1ccc(cc1)-c1ccc(NC(=O)C2CCN(CC2)C(=O)c2ccco2)cc1)C1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C34H34N4O6/c39-31(25-13-17-37(18-14-25)33(41)29-3-1-21-43-29)35-27-9-5-23(6-10-27)24-7-11-28(12-8-24)36-32(40)26-15-19-38(20-16-26)34(42)30-4-2-22-44-30/h1-12,21-22,25-26H,13-20H2,(H,35,39)(H,36,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	2.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jiangnan University Curated by ChEMBL					Assay Description Inhibition of GST-tagged PTP1B (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assay				Bioorg Med Chem Lett 30: (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM124241 (N,N'-([1,1'-biphenyl]-4,4'-diyl)bis(1-...) Show SMILES O=C(Nc1ccc(cc1)-c1ccc(NC(=O)C2CCN(CC2)C(=O)c2ccco2)cc1)C1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C34H34N4O6/c39-31(25-13-17-37(18-14-25)33(41)29-3-1-21-43-29)35-27-9-5-23(6-10-27)24-7-11-28(12-8-24)36-32(40)26-15-19-38(20-16-26)34(42)30-4-2-22-44-30/h1-12,21-22,25-26H,13-20H2,(H,35,39)(H,36,40)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jiangnan University					Assay Description IC50 values were determined by pNPP assay.				Bioorg Med Chem Lett 24: 1889-94 (2014) Article DOI: 10.1016/j.bmcl.2014.03.015 BindingDB Entry DOI: 10.7270/Q2PC3122
					More data for this Ligand-Target Pair