Found 5 hits for monomerid = 124350 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM124350
(CHEMBL2071607 | US8759532, 1)Show SMILES FC(F)(F)c1cccnc1Oc1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1 Show InChI InChI=1S/C20H12F3N5O/c21-20(22,23)15-2-1-9-25-18(15)29-14-6-4-13(5-7-14)26-19-27-16-8-3-12(11-24)10-17(16)28-19/h1-10H,(H2,26,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
| US Patent
| n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this Ligand-Target Pair | |
Casein kinase I isoform alpha
(Homo sapiens (Human)) | BDBM124350
(CHEMBL2071607 | US8759532, 1)Show SMILES FC(F)(F)c1cccnc1Oc1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1 Show InChI InChI=1S/C20H12F3N5O/c21-20(22,23)15-2-1-9-25-18(15)29-14-6-4-13(5-7-14)26-19-27-16-8-3-12(11-24)10-17(16)28-19/h1-10H,(H2,26,27,28) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 1.21E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of CK1alpha by Lance assay |
Bioorg Med Chem Lett 22: 5392-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.046 BindingDB Entry DOI: 10.7270/Q2CF9R6Q |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM124350
(CHEMBL2071607 | US8759532, 1)Show SMILES FC(F)(F)c1cccnc1Oc1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1 Show InChI InChI=1S/C20H12F3N5O/c21-20(22,23)15-2-1-9-25-18(15)29-14-6-4-13(5-7-14)26-19-27-16-8-3-12(11-24)10-17(16)28-19/h1-10H,(H2,26,27,28) | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 5.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of CK1delta by Lance assay |
Bioorg Med Chem Lett 22: 5392-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.046 BindingDB Entry DOI: 10.7270/Q2CF9R6Q |
More data for this Ligand-Target Pair | |
Casein kinase I
(Homo sapiens (Human)) | BDBM124350
(CHEMBL2071607 | US8759532, 1)Show SMILES FC(F)(F)c1cccnc1Oc1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1 Show InChI InChI=1S/C20H12F3N5O/c21-20(22,23)15-2-1-9-25-18(15)29-14-6-4-13(5-7-14)26-19-27-16-8-3-12(11-24)10-17(16)28-19/h1-10H,(H2,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 6.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting |
Bioorg Med Chem Lett 22: 5392-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.046 BindingDB Entry DOI: 10.7270/Q2CF9R6Q |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM124350
(CHEMBL2071607 | US8759532, 1)Show SMILES FC(F)(F)c1cccnc1Oc1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1 Show InChI InChI=1S/C20H12F3N5O/c21-20(22,23)15-2-1-9-25-18(15)29-14-6-4-13(5-7-14)26-19-27-16-8-3-12(11-24)10-17(16)28-19/h1-10H,(H2,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 3.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta by AlphaScreen assay |
Bioorg Med Chem Lett 22: 5392-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.046 BindingDB Entry DOI: 10.7270/Q2CF9R6Q |
More data for this Ligand-Target Pair | |