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SMILES: Cc1c(nc2cc(F)ccc2c1N1CC(C)(C)c2ncc(cc12)C1=CCOCC1)-c1ccccn1

InChI Key: InChIKey=HKXAQMNVSYLNCH-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124736   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM124736
PNG
(US8765940, 4-(6-(3,6-dihydro-2H-pyran-4-yl)-3,3-di...)
Show SMILES Cc1c(nc2cc(F)ccc2c1N1CC(C)(C)c2ncc(cc12)C1=CCOCC1)-c1ccccn1 |t:27|
Show InChI InChI=1S/C29H27FN4O/c1-18-26(23-6-4-5-11-31-23)33-24-15-21(30)7-8-22(24)27(18)34-17-29(2,3)28-25(34)14-20(16-32-28)19-9-12-35-13-10-19/h4-9,11,14-16H,10,12-13,17H2,1-3H3
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MMDB

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PC cid
PC sid
UniChem
US Patent
 6.47n/an/an/an/an/an/a7.0n/a



Amgen Inc.

US Patent


Assay Description
A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...

US Patent US8765940 (2014)


BindingDB Entry DOI: 10.7270/Q2WW7G94
More data for this
Ligand-Target Pair